Search on: BETA TRANSDUCIN 
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Descriptor English:   Transducin 
Descriptor Spanish:   Transducina 
Descriptor Portuguese:   Transducina 
Synonyms English:   Transducin G-Protein (Gt)
Transducin, alpha Subunit
Transducin, beta Subunit
Transducin, gamma Subunit
G Protein, Inhibitory Gt
G-Protein Gt, Transducin
Gt G-Protein, Inhibitory
Gt, Transducin G Protein
Inhibitory Gt G-Protein
Transducin G-Protein Gt
alpha Subunit Transducin
alpha Transducin
beta Subunit Transducin
beta Transducin
gamma Subunit Transducin
gamma Transducin
alpha-Transducin
beta-Transducin
gamma-Transducin
G-Protein, Inhibitory Gt
Gt, Transducin G-Protein  
Tree Number:   D08.811.277.040.330.300.200.800
D12.644.360.375.940
D12.776.157.325.332.940
D12.776.476.375.940
D12.776.543.325.800
Definition English:   A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells. 
Indexing Annotation English:   alpha, beta and gamma transducins refer to its subunits
History Note English:   89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   23850 
Unique Identifier:   D015293 

Occurrence in VHL: 		 

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